*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Leuprolide-d5 Acetate</strong> is a deuterated internal standard for quantitative analysis of the GnRH agonist Leuprolide. Synthesized via solid-phase peptide synthesis with isotopic substitution, its molecular formula is C<sub>28</sub>H<sub>40</sub>N<sub>8</sub>O<sub>7</sub>D<sub>5</sub>·C<sub>2</sub>H<sub>4</sub>O<sub>2</sub> (CAS 161297-34-3).</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical QC:</strong> Validating assay and impurity profiles in drug substance batches.</li>
<li><strong>Metabolic Studies:</strong> Tracing pharmacokinetics and metabolism pathways in clinical trials.</li>
<li><strong>Mass Spectrometry:</strong> Serving as a stable reference for LC-MS/MS quantification.</li>
</ul>
<h3>Precautions</h3>
<p>Store at -20°C under inert atmosphere to prevent hydrolysis. Handle with PPE; avoid inhalation or skin contact due to potential sensitization during weighing processes.</p>