Orexin B, human (TFA) is a 28 amino acid peptide, derived from the proteolytic amino acid precursor pre-orexin, and belongs to the endogenous agonist of the Orexin receptor. Storage method: freeze-dry at -20°C and store away from light Remarks: For research only, not for humans
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L-Methioninamide, L-arginyl-L-serylglycine is a specialized synthetic peptide derivative widely utilized in advanced biochemical research and pharmaceutical development. Its molecular formula is C18H35N7O4S, corresponding to a precise molecular weight of approximately 429.56 g/mol. This compound is cataloged under the CAS number 100263-63-6, ensuring its unique identification within global chemical databases. Structurally, it comprises a methioninamide moiety linked to a tripeptide sequence of arginine, serine, and glycine, creating a complex molecule with distinct physicochemical properties suitable for targeted biological interactions.
The primary application of this substance lies in enzymatic studies and protein synthesis research. Researchers frequently employ it as a substrate or inhibitor to investigate the activity profiles of specific proteases and peptidases, particularly those involved in metabolic pathways regulating amino acid metabolism. Due to the presence of the methioninamide group, which mimics natural peptide bonds but offers enhanced stability against certain degradative enzymes, it serves as an invaluable tool for studying enzyme kinetics and mechanism of action. Furthermore, its structural complexity makes it a candidate for exploring structure-activity relationships (SAR) in drug discovery programs aiming to develop novel therapeutic agents targeting metabolic disorders or inflammatory conditions.
In addition to basic research, this peptide derivative finds utility in high-performance liquid chromatography (HPLC) method development. Scientists use it as a reference standard to calibrate analytical instruments and validate separation techniques for similar bioactive compounds. The availability of high-purity batches allows for reproducible experimental results, which is critical in academic and industrial laboratories. While not currently a mainstream commercial drug, its role in elucidating fundamental biological processes remains significant. As the field of peptide therapeutics expands, derivatives like L-Methioninamide, L-arginyl-L-serylglycine may offer new insights into designing stable, bioavailable peptides with improved pharmacological profiles. Continued investigation into its specific binding affinities and metabolic fate could unlock further applications in personalized medicine and targeted therapy strategies.