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Other Specialized Reagents

L(+)-Leucinol

Category:

Other Specialized Reagents

CAS NO:

7533-40-6

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

7533-40-6

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

L(+)-Leucinol, chemically known as (2S)-4-amino-3-methylbutan-1-ol, is a chiral amino alcohol derivative of the essential amino acid L-leucine. With the molecular formula C6H15NO and a CAS registry number of 1087-94-3, this compound serves as a valuable building block in modern organic synthesis and pharmaceutical research. Structurally, it retains the distinctive branched-chain hydrophobic side chain characteristic of leucine while incorporating a primary amine and a primary alcohol group on the terminal carbon chain. This unique dual-functional nature allows for versatile chemical modifications, making it highly sought after by medicinal chemists designing peptidomimetics and bioactive molecules. In the pharmaceutical industry, L(+)-Leucinol is primarily utilized as a chiral intermediate for the asymmetric synthesis of complex drug candidates. Its stereochemistry is crucial for ensuring the biological efficacy and safety of final therapeutic agents, particularly in the development of antibiotics, antiviral drugs, and enzyme inhibitors where specific spatial arrangements are required for receptor binding. The compound facilitates the construction of beta-amino acid scaffolds, which often exhibit enhanced metabolic stability compared to their natural peptide counterparts. Furthermore, due to its solubility properties and reactivity profile, it finds applications in materials science, specifically in the formulation of specialized surfactants and chiral ligands for transition metal catalysis. The "L(+)" designation indicates that the molecule possesses the S-configuration at the chiral center and rotates plane-polarized light in a dextrorotatory direction, distinguishing it from its enantiomer or racemic mixtures. High optical purity is typically maintained during production to ensure consistent performance in stereoselective reactions. While not a bulk commodity chemical, L(+)-Leucinol is an indispensable tool for academic laboratories and industrial R&D departments focused on advancing novel therapeutics. Its availability in high purity grades supports rigorous quality control standards necessary for clinical trial materials. As the demand for precision medicine grows, the role of such chiral intermediaries becomes increasingly pivotal in accelerating the discovery pipeline for next-generation treatments targeting difficult-to-treat diseases.