L-Glutamicacid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-,calcium salt (1:1), (S)-;
L-Glutamic acid,N-[4-[[[(6S)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-,calcium salt (1:1) (9CI);
Bodyfolin;
LMCA;
L-Glutamic acid,N-[4-[[[(6S)-2-amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-,calcium salt (1:1);
Nutrifolin
CAS:151533-22-1
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L-5-Methyltetrahydrofolate calcium, often referred to as L-methylfolate calcium salt, is the active form of vitamin B9 and a critical cofactor in one-carbon metabolism. Its chemical formula is C20H28CaN8O13, with the specific CAS number 86745-03-7. This compound represents the biologically active derivative of folic acid, distinguished by its ability to bypass enzymatic reduction steps required for synthetic folates to become metabolically functional.
The primary significance of this molecule lies in its role in methylation processes, particularly the conversion of homocysteine to methionine. Elevated homocysteine levels are associated with cardiovascular risks and neurological disorders; thus, L-5-MTHF plays a vital role in maintaining healthy homocysteine concentrations. Furthermore, it is essential for DNA synthesis and repair, making it indispensable for cell division and tissue growth. Unlike synthetic folic acid, which requires genetic conversion via the MTHFR enzyme, L-5-MTHF can be directly utilized by the body. This feature makes it an ideal supplement for individuals with MTHFR gene polymorphisms, who may otherwise struggle to process standard folic acid effectively.
In the pharmaceutical and dietary supplement industries, L-5-Methyltetrahydrofolate calcium is widely used to treat folate deficiencies, support pregnancy health, and manage mood disorders such as depression when used adjunctively with antidepressants. Its calcium salt form enhances stability and bioavailability compared to free acid forms. As a highly potent nutritional agent, it supports cognitive function, fetal neural tube development, and overall metabolic health. Regulatory bodies globally recognize its safety profile for human consumption at recommended dosages. With increasing awareness of genetic variations affecting nutrient absorption, this advanced form of folate has become a cornerstone in modern nutritional therapy, offering a reliable solution for those seeking optimal methylation support without the limitations of traditional synthetic alternatives.