Kisspeptin-10, human is an effective vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human can inhibit tumor metastasis through its receptor GPR54. Kisspeptin-10-gpr54 system plays an important role in the development of embryonic kidney. Kisspeptin-10 / GPR54 signal induces osteoblast differentiation through nfatc4 mediated BMP2 expression. The level of kisspeptin-10 is helpful to identify the benign and malignant SRM.