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Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3weeks
Product Description
Jagged-1 (188-204) TFA is a fragment of peptide in JAG-1 protein, which contains 17 amino acids in its sequence. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells, which can induce the maturation of monocyte-derived human dendritic cells.
AI Product Description
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Jagged-1 (188-204) TFA is a synthetic peptide fragment of the Notch ligand Jagged-1, typically supplied as a trifluoroacetic acid salt to ensure solubility. This segment corresponds to residues 188-204 and serves as a critical tool for investigating Notch signaling pathways in developmental biology and oncology research.</p>
<h3>Application</h3>
<ul>
<li><strong>Drug Discovery:</strong> Used in high-throughput screening assays to identify inhibitors or modulators of the Notch-Jagged interaction.</li>
<li><strong>Biochemical Research:</strong> Employed in binding studies and epitope mapping to characterize receptor-ligand affinity.</li>
<li><strong>Cancer Biology:</strong> Applied in vitro to study tumor cell differentiation and angiogenesis mechanisms driven by Notch signaling.</li>
</ul>
<h3>Precautions</h3>
<p>This reagent is strictly for laboratory research use only and is not approved for clinical therapeutic applications. Store lyophilized powder at -20°C under desiccated conditions; avoid repeated freeze-thaw cycles to maintain structural integrity.</p>
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