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CAS NO:
330645-87-9
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Basic Info
CAS Number
330645-87-9
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
5g,10g,25g,50g,100g,500g
Minimum Order Quantity
5g
Delivery Cycle
In stock or 1-2weeks
Product Description
Hangzhou Go Top Peptide Biotech Co.,Ltd. - a reliable supplier of peptides synthesis.Our clients include * the pharma, cosmetic and biotech companies and research institutions worldwide. Welcome to contact us by email to sales22@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
HCTU, chemically known as 2-(6-chlorobenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, is a widely utilized coupling reagent in modern organic synthesis and peptide chemistry. With the molecular formula C15H18ClF6N4OP and CAS number 102074-93-9, this compound serves as a highly efficient alternative to traditional carbodiimide-based reagents like HOBt or DCC. Its primary function is to activate carboxylic acids, facilitating their reaction with amines to form amide bonds under mild conditions with minimal racemization of chiral centers.
The structure of HCTU features a uronium core linked to a chlorinated benzotriazole moiety, which enhances its solubility in common polar aprotic solvents such as DMF, NMP, and DCM. This solubility profile makes it particularly advantageous for solid-phase peptide synthesis (SPPS) and solution-phase coupling reactions where high purity and yield are critical. Compared to its non-halogenated analogues, HCTU offers superior stability and reduced side reactions, ensuring cleaner product profiles and easier purification processes. The presence of the hexafluorophosphate anion contributes to its ionic character, further improving performance in complex synthetic environments.
In the pharmaceutical industry, HCTU is indispensable for constructing peptide drugs, including therapeutic agents targeting oncology, infectious diseases, and metabolic disorders. It enables the rapid assembly of short and long peptide sequences with high fidelity, supporting the development of novel bioactive molecules. Additionally, researchers utilize HCTU in the synthesis of heterocyclic compounds and other nitrogen-containing architectures where amide bond formation is a key step. Its efficiency allows for shorter reaction times and lower catalyst loading, contributing to cost-effective manufacturing processes. Despite its potency, proper handling is essential due to potential sensitization risks associated with benzotriazole derivatives. Overall, HCTU remains a cornerstone reagent in medicinal chemistry laboratories worldwide, driving innovation in drug discovery and materials science through its reliable and versatile coupling capabilities.
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Copyright 2006-2025 (All Rights Reserved)
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