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<h3>Overview</h3>
<p>Ganciclovir-d5 is a deuterated isotopologue of the antiviral drug ganciclovir, synthesized via catalytic deuteration for use as an analytical standard in <strong>LC-MS/MS</strong> quantification. Its molecular formula is C9H10D5N5O4 with CAS number 128986-78-9.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical R&D:</strong> Serves as an internal standard for validating assay methods and stability testing of generic formulations.</li>
<li><strong>Clinical Diagnostics:</strong> Enables precise monitoring of patient plasma concentrations during anti-CMV therapy.</li>
<li><strong>Metabolic Research:</strong> Facilitates detailed pharmacokinetic profiling and metabolic pathway elucidation studies.</li>
</ul>
<h3>Precautions</h3>
<p>Requires storage at -20°C under inert atmosphere to prevent hydrolysis. Personnel must utilize appropriate PPE including nitrile gloves and fume hoods due to potential reproductive toxicity associated with ganciclovir derivatives.</p>