Foxy-5 (TFA) is a WNT5A agonist, a peptide composed of 6 amino acids. Foxy-5 (TFA) can trigger cytoplasmic free calcium signal transduction without affecting the activation of β-catenin, and can inhibit epithelial cancer Cell migration and invasion. Foxy-5 (TFA) can effectively reduce the metastasis and spread of prostate cancer cells with low WNT5A expression in an orthotopic mouse model.