Product Description
Exenatide is a synthetic product of exendin-4, an analog of glucagon-like peptide-1 (GLP-1). Exendin-4 (3-39) is a fragment of Exenatide peptide, consisting of 37 amino acids , Retaining most of the structure of Exenatide. The Asn residues in its structure are prone to deamidation reaction to form Asp at high pH and high temperature. His and Trp residues are more prone to oxidation. The peptide bond formed by Asp is more prone to hydrolysis and cleavage than other peptide bonds, except for Gly , All other amino acid residues are prone to racemization reaction under base catalysis, and Thr residues can be degraded by β elimination under alkaline conditions. Therefore, in the process of peptide synthesis, a practical and reasonable production process is required.