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Other Specialized Reagents

Ethyl trifluoroacetate

Category:

Other Specialized Reagents

CAS NO:

383-63-1

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

383-63-1

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

Ethyl trifluoroacetate, chemically known as ethyl 2,2,2-trifluoroacetate, is a versatile fluorinated organic compound widely utilized in industrial and laboratory settings. Its molecular formula is C4H5F3O2, and it is identified by the CAS number 376-18-7. This colorless liquid possesses a distinct ether-like odor and exhibits moderate solubility in water while being highly miscible with most organic solvents. The presence of the trifluoroacetyl group significantly alters its reactivity compared to standard esters, making it an essential building block in synthetic chemistry. The primary application of ethyl trifluoroacetate lies in organic synthesis, where it serves as a potent acylating agent. It is frequently employed to introduce the trifluoroacetyl moiety into various substrates, facilitating the production of pharmaceutical intermediates, agrochemicals, and advanced materials. Due to the electron-withdrawing nature of the fluorine atoms, the carbonyl carbon is highly electrophilic, allowing for efficient nucleophilic attack under mild conditions. This property is particularly valuable in protecting group strategies, where the trifluoroacetyl group can be easily installed and subsequently removed without affecting other sensitive functional groups within complex molecules. Beyond pharmaceutical manufacturing, this compound plays a crucial role in the development of specialized polymers and fluorochemicals. It acts as a precursor for synthesizing trifluoroacetic acid derivatives, which are critical in the production of high-performance coatings and surfactants. Furthermore, its unique physicochemical properties make it useful as a solvent or reaction medium in specific electrochemical and analytical applications. Researchers also utilize it in the study of reaction kinetics and mechanistic pathways involving fluorinated species. Safety protocols must be strictly followed during handling, as with many volatile organic compounds, ensuring proper ventilation and protective equipment to mitigate potential health risks associated with inhalation or skin contact. Overall, Ethyl trifluoroacetate remains a cornerstone reagent in modern fluorine chemistry, bridging the gap between fundamental research and large-scale industrial production.