*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Epalrestat-d5 is a <strong>deuterated isotopologue</strong> of the aldose reductase inhibitor Epalrestat, synthesized via catalytic deuterium exchange. Its molecular formula is C<sub>19</sub>H<sub>14</sub>D<sub>5</sub>NO<sub>2</sub>, serving as a critical reference standard for pharmacokinetic studies and metabolic profiling in pharmaceutical development.</p>
<h3>Application</h3>
<ul>
<li><strong>Clinical Trials:</strong> Utilized as an internal standard in LC-MS/MS assays to quantify epalrestat concentrations in human plasma and urine samples.</li>
<li><strong>Metabolic Research:</strong> Enables precise tracking of drug metabolism pathways and stability assessment under varying physiological conditions.</li>
<li><strong>Quality Control:</strong> Applied in validation protocols for analytical methods ensuring accuracy in drug substance testing.</li>
</ul>
<h3>Precautions</h3>
<p>Store at -20°C in airtight containers to prevent degradation. Handle with appropriate PPE in well-ventilated fume hoods. Not intended for direct clinical administration; strictly limited to research use only.</p>