MF:C17H25N3O5S?3H2O
MW:437.51
Description:Almost white to light yellow crystalline power.
Identification:
IR:comparable IR spectra with standard spectra
UV: UV absorption spectrum of sample solution and standard solution should exhibit maima and minima at same wavelengh
Water content(By KF):
Between 11.4%w/w and 13.4%w/w
Specific optical rotation:-17° to -21°(at 20℃ ,OAB 0.22g/water 50ml, 100mm)
Heavy metals:Not more than 0.001%(10ppm)
Residue on ignition:Nor more than 0.1%w/w
Assay (By HPLC):NLT 98.0%w/w(OAB)
Bacterial endotoxins:NMT 0.125 USP EU/mg
Abstract:Meropenem which was synthesized in 1990 for the first time is the first 1β-methyl carbapenem antibiotic. It is stable to β-lactamases and renal dehydropeptidase-Ⅰ(DHP-Ⅰ),and can be used for mono-therapy and not necessary to be combined with dehydropeptidase inhibitors.