Colivelin TFA is a neuroprotective peptide with brain permeability and an effective activator of STAT3, consisting of 26 amino acids. Colivelin TFA inhibits neuronal death in vitro by activating STAT3; at the same time, Colivelin TFA has long-term beneficial effects on neurotoxicity, Aβ deposition, neuronal cell apoptosis, and neurodegenerative diseases. Colivelin TFA can be used for research on Alzheimer's disease and ischemic brain injury.