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CAS NO:
26198-19-6
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Basic Info
CAS Number
26198-19-6
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
5g,10g,25g,50g,100g,500g
Minimum Order Quantity
5g
Delivery Cycle
In stock or 1-3weeks
Product Description
Hangzhou Go Top Peptide Biotech Co.,Ltd. - a reliable supplier of peptides synthesis.Our clients include * the pharma, cosmetic and biotech companies and research institutions worldwide. Welcome to contact us by email to sales17@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Cl-HOBt, chemically known as 1-hydroxybenzotriazole chloride or more accurately in its activated form often associated with HOBt derivatives used in peptide synthesis, is a pivotal reagent in modern organic chemistry. While the specific monomeric species "Cl-HOBt" is not a standard commercial standalone product compared to its hydroxylamine counterpart (HOBt) or its ethyl ester derivative (HOBT-Et), it generally refers to activated intermediates or specific salt forms utilized to enhance coupling efficiency. In many contexts, users may refer to 1-chlorobenzotriazole or activated esters derived from HOBt, which serve as superior leaving groups in nucleophilic substitution reactions. The primary molecular framework involves a benzotriazole ring substituted with a chlorine atom, creating a highly reactive electrophilic center ideal for acylation and amidation processes.
The most common application of HOBt-based reagents, including chlorinated variants, lies in solid-phase peptide synthesis (SPPS) and solution-phase amide bond formation. These compounds act as additives that suppress racemization of chiral amino acids during the activation step. By forming an active ester intermediate, Cl-HOBt facilitates the rapid reaction between carboxylic acids and amines under mild conditions, significantly improving yield and purity. This capability is crucial in pharmaceutical manufacturing where stereochemical integrity is paramount. Furthermore, these reagents are employed in the synthesis of complex heterocycles, macrocycles, and various bioactive molecules, serving as key building blocks in medicinal chemistry research.
From a safety perspective, while HOBt derivatives can pose explosion hazards when dry and heated, the chlorinated forms require careful handling due to their high reactivity and potential toxicity. Proper storage in cool, dry environments away from incompatible bases is essential. Although exact CAS numbers vary depending on the specific salt or solvate form, they typically fall within the range of benzotriazole halogenated derivatives. Overall, Cl-HOBt represents an indispensable tool for chemists aiming to construct complex molecular architectures with high precision and efficiency, bridging the gap between theoretical synthesis and practical industrial application in drug discovery pipelines.
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