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Other Specialized Reagents

Celecoxib

Category:

Other Specialized Reagents

CAS NO:

169590-42-5

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

169590-42-5

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the sulfonamide class of nonsteroidal anti-inflammatory drugs (NSAIDs). Its chemical formula is C17H14F3N3O2S, and it carries the CAS Registry Number 169590-42-5. Structurally, it features a pyrazole ring substituted with a trifluoromethyl group and a phenylsulfonyl moiety, which contributes to its high specificity for the COX-2 enzyme while sparing COX-1. This selectivity allows Celecoxib to provide potent anti-inflammatory, analgesic, and antipyretic effects with a significantly reduced risk of gastrointestinal ulcers and bleeding compared to traditional non-selective NSAIDs like ibuprofen or naproxen. Clinically, Celecoxib is primarily indicated for the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It effectively reduces joint pain, stiffness, and inflammation associated with these chronic conditions. Additionally, it is approved for the treatment of acute pain in adults, including post-operative dental pain, and for managing menstrual cramps. In specific cases, such as familial adenomatous polyposis (FAP), it serves as an adjunct therapy to reduce the number of colorectal polyps. The drug is typically administered orally in capsule form, with dosages varying based on the condition being treated and individual patient response. Despite its therapeutic benefits, Celecoxib carries important safety warnings. Patients with a known hypersensitivity to sulfonamides should avoid this medication due to the sulfonyl group in its structure. Like other NSAIDs, it may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, particularly with long-term use or in patients with existing heart disease. Renal impairment and liver dysfunction are also potential concerns requiring careful monitoring. While generally well-tolerated, common side effects can include upper respiratory infections, sinusitis, and abdominal discomfort. Physicians must weigh the cardiovascular risks against the gastrointestinal benefits when prescribing Celecoxib, ensuring it is used at the lowest effective dose for the shortest duration necessary to achieve therapeutic goals.