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Prophylactic Biological Products
CAS NO:
179463-17-3
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Basic Info
CAS Number
179463-17-3
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Product Description
Caspofungin Acetate is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. Caspofungin inhibits 1,3-beta-glucan synthase, resulting in decreased synthesis of beta(1,3)-D-glucan (an essential component of the fungal cell wall), weakening of the fungal cell wall, and fungal cell wall rupture. This agent is active against Aspergillus and Candida species.
AI Product Description
*The following content is generated by AI and is for reference only.
Caspofungin acetate is a potent antifungal agent belonging to the echinocandin class, widely recognized for its efficacy against invasive fungal infections. With the Chemical Abstracts Service (CAS) registry number 162593-80-4, this compound is chemically defined by the molecular formula C49H70N10NaO14S. It functions primarily as a non-competitive inhibitor of beta-(1,3)-D-glucan synthase, an essential enzyme complex in the synthesis of the fungal cell wall. By disrupting the production of glucan, Caspofungin acetate compromises cell wall integrity, leading to osmotic instability and subsequent cell death. This mechanism distinguishes it from azoles and polyenes, offering a unique therapeutic profile with minimal cross-resistance.
Clinically, Caspofungin acetate is indicated for the treatment of invasive candidiasis, including candidemia and deep-seated organ infections caused by susceptible strains of Candida species. Furthermore, it serves as a salvage therapy for invasive aspergillosis in patients who are refractory to or intolerant of other antifungal treatments such as amphotericin B or voriconazole. Its broad spectrum of activity extends to various Candida species, including fluconazole-resistant isolates like Candida krusei and Candida glabrata. The drug is administered intravenously due to poor oral bioavailability, typically given once daily after an initial loading dose.
Safety profiles indicate that Caspofungin acetate is generally well-tolerated, with common adverse effects including fever, gastrointestinal disturbances, headache, and phlebitis at the injection site. Unlike some other antifungals, it exhibits low nephrotoxicity and hepatotoxicity, making it a preferred option for immunocompromised patients, such as those undergoing chemotherapy or organ transplantation. While it does not penetrate the central nervous system effectively, limiting its use in meningitis, its safety and efficacy in systemic infections remain paramount. As resistance patterns evolve, Caspofungin acetate continues to be a cornerstone in managing severe mycoses, often utilized in combination therapies to enhance clinical outcomes. Ongoing research explores its potential applications in broader fungal pathologies, reinforcing its status as a critical tool in modern antimicrobial pharmacotherapy.
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