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Prophylactic Biological Products
CAS NO:
486460-32-6
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Basic Info
CAS Number
486460-32-6
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Product Description
Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar. Sitagliptin was granted FDA approval on October 16, 2006.
AI Product Description
*The following content is generated by AI and is for reference only.
Sitagliptin is a highly effective oral antidiabetic medication belonging to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. Chemically, it is known by the systematic name (3R)-3-amino-1-(3-fluoro-2-methyl-5-oxo-2,5-dihydro-1H-pyrazolo[3,4-d]pyridine-6-carbonyl)piperidine and carries the molecular formula C16H15F6N5O. Its unique CAS registry number is 486460-32-2, which serves as a definitive identifier for this specific chemical entity in scientific databases and regulatory documents. The molecule features a distinctive pyrazolopyridine core structure that allows it to bind selectively and reversibly to the DPP-4 enzyme with high affinity.
The primary clinical utility of Sitagliptin lies in the management of type 2 diabetes mellitus in adults. It functions by inhibiting the DPP-4 enzyme, which is responsible for the rapid degradation of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By preventing the breakdown of these hormones, Sitagliptin enhances their physiological activity. Elevated levels of active GLP-1 and GIP lead to a glucose-dependent increase in insulin secretion from pancreatic beta cells while simultaneously suppressing inappropriate glucagon release from alpha cells. This dual mechanism effectively lowers blood glucose levels without stimulating insulin production when glucose concentrations are already low, thereby minimizing the risk of hypoglycemia compared to sulfonylureas or insulin therapies.
Clinically, Sitagliptin is often prescribed as monotherapy for patients who cannot tolerate metformin or as an adjunctive therapy combined with other antidiabetic agents like metformin, sulfonylureas, or thiazolidinediones. It is available under various brand names globally, most notably Januvia. Due to its favorable safety profile, weight neutrality, and convenient once-daily dosing regimen, it has become a cornerstone in modern diabetes treatment guidelines. Extensive clinical trials have demonstrated its efficacy in reducing HbA1c levels significantly over long-term periods. Furthermore, it does not typically cause weight gain, making it an attractive option for patients concerned about metabolic side effects. As research continues, ongoing studies explore its potential cardiovascular benefits and role in broader metabolic syndrome management, solidifying its status as a critical therapeutic agent in global healthcare systems.
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