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Other Specialized Reagents

candesartan cilexetil

Category:

Other Specialized Reagents

CAS NO:

145040-37-5

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

145040-37-5

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Low toxicity herbicide, diphenyl ether herbicide, selective herbicide in rice field, can only be used for stem and leaf treatment, shoot pretreatment is ineffective. Main control barnyard grass, thousand gold and other grass weeds

AI Product Description

*The following content is generated by AI and is for reference only.

Candesartan cilexetil is a widely utilized prodrug in the pharmaceutical industry, primarily serving as an angiotensin II receptor blocker (ARB) for the management of hypertension and heart failure. Chemically, its molecular formula is C33H30N6O6, with a molecular weight of approximately 582.63 g/mol. The compound is identified by the CAS Registry Number 138746-98-4. As a prodrug, candesartan cilexetil itself possesses no pharmacological activity; however, upon oral administration, it undergoes rapid hydrolysis in the gastrointestinal tract and liver to release the active moiety, candesartan. This active metabolite selectively and competitively blocks the binding of angiotensin II to the AT1 receptors found on vascular smooth muscle cells and adrenal glands. By inhibiting this interaction, the drug prevents vasoconstriction and aldosterone secretion, leading to vasodilation and reduced blood volume, which effectively lowers systemic blood pressure. The therapeutic applications of candesartan cilexetil are extensive. It is the first-line treatment for essential hypertension in adults and children over six years old. Furthermore, it plays a crucial role in reducing cardiovascular morbidity and mortality in patients with chronic heart failure who cannot tolerate ACE inhibitors. Clinical studies have demonstrated its efficacy in preserving renal function and preventing left ventricular hypertrophy. Unlike some other antihypertensive agents, candesartan cilexetil offers a favorable side effect profile, with cough being significantly less common compared to ACE inhibitor therapy. Its long half-life allows for once-daily dosing, enhancing patient compliance. The drug is available in various tablet strengths, typically ranging from 4 mg to 32 mg, facilitating flexible dosage adjustments based on individual patient response. Extensive global clinical trials have confirmed its safety and efficacy across diverse populations, making it a cornerstone medication in modern cardiovascular care protocols. Manufacturers worldwide produce this compound under strict regulatory guidelines to ensure high purity and bioavailability, supporting its status as a vital component in the global fight against cardiovascular diseases.