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Other Specialized Reagents

BOC-L-LEUCINOL

Category:

Other Specialized Reagents

CAS NO:

82010-31-9

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

82010-31-9

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

BOC-L-Leucinol, chemically designated as N-tert-butoxycarbonyl-L-leucinal, is a specialized protected amino alcohol derivative widely utilized in modern organic synthesis and pharmaceutical research. Its molecular formula is C12H23NO3, and it carries the CAS Registry Number 89760-54-5. This compound serves as a crucial building block for the construction of complex peptidomimetics and bioactive molecules. The molecule features a leucine backbone where the alpha-amino group is protected by a tert-butoxycarbonyl (Boc) group, while the carboxylic acid functionality has been selectively reduced to a primary alcohol. The primary utility of BOC-L-Leucinol lies in its role as an intermediate for synthesizing protease inhibitors, particularly those targeting cysteine and serine proteases involved in viral replication and cellular regulation. In medicinal chemistry, researchers frequently employ this reagent to introduce specific steric and electronic properties into drug candidates, enhancing their metabolic stability and binding affinity. The Boc protecting group ensures that the amine remains inert during various synthetic transformations, allowing for precise control over reaction pathways before final deprotection yields the free amine or aldehyde derivatives. Furthermore, BOC-L-Leucinol is instrumental in solid-phase peptide synthesis and the development of chiral catalysts. Its stereochemical integrity, derived from natural L-leucine, is essential for producing enantiomerically pure compounds required in clinical applications. The compound is typically supplied as a white to off-white crystalline solid, soluble in common organic solvents such as dichloromethane, ethyl acetate, and methanol. Due to its high reactivity and specific structural features, it is indispensable in the discovery of novel therapeutics for conditions ranging from HIV/AIDS to cancer. Researchers must handle this material with standard laboratory precautions, ensuring storage under cool, dry conditions to maintain stability. As a versatile tool in chemical biology, BOC-L-Leucinol continues to facilitate breakthroughs in understanding protein-ligand interactions and designing next-generation pharmacological agents with improved efficacy and safety profiles.