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Prophylactic Biological Products
CAS NO:
1118567-05-7
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Basic Info
CAS Number
1118567-05-7
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Product Description
Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor. Similar to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a methylene bridge. In January 2023, bexagliflozin was approved by the FDA for the treatment of adults with type 2 diabetes. Its use is not recommended in patients with type 1 diabetes since it may increase their risk of diabetic ketoacidosis.
AI Product Description
*The following content is generated by AI and is for reference only.
Bexagliflozin is a novel oral antidiabetic agent belonging to the class of sodium-glucose cotransporter 2 (SGLT2) inhibitors. Its chemical identity is defined by the molecular formula C19H24N2O5 and it carries the CAS Registry Number 2076383-37-6. This compound represents a significant advancement in the management of type 2 diabetes mellitus, offering a distinct mechanism of action compared to traditional therapies like insulin sensitizers or secretagogues.
The primary therapeutic application of bexagliflozin involves lowering blood glucose levels in adult patients with type 2 diabetes who have not achieved adequate glycemic control through diet and exercise alone. Unlike SGLT1 inhibitors that primarily affect the intestine, bexagliflozin selectively inhibits SGLT2 in the proximal renal tubules of the kidney. By blocking this transporter, the drug prevents the reabsorption of filtered glucose, thereby promoting its excretion into the urine (glucosuria). This process effectively reduces systemic hyperglycemia without stimulating insulin secretion, which minimizes the risk of hypoglycemia when used as monotherapy.
Beyond glycemic control, bexagliflozin demonstrates potential cardiovascular and renal protective benefits, consistent with the broader class of SGLT2 inhibitors. Clinical studies suggest it may contribute to modest weight loss and blood pressure reduction due to the osmotic diuretic effect of urinary glucose excretion. The drug has received regulatory approval in South Korea for the treatment of type 2 diabetes, marking it as an important addition to the global pharmacological arsenal against metabolic disorders. Its selective profile aims to optimize efficacy while maintaining a favorable safety profile regarding adverse events such as genital infections, although monitoring remains essential. As research continues, bexagliflozin stands poised to offer clinicians a versatile tool for managing complex diabetic cases, potentially improving long-term patient outcomes and quality of life through its unique renal-centric mechanism of action.
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