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CAS NO:
217082-57-0
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Apelin-17/Apelin Precursor (61-77)/Preproapelin (61-77)
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North America,Central/South America,Western Europe,Eastern Europe,
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Hangzhou Go Top Peptide Biotech Co.,Ltd.
2
Years
Basic Info
CAS Number
217082-57-0
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Apelin is the endogenous ligand of the transmembrane G protein-coupled receptor APJ, which is widely distributed in tissues and expressed in cardiovascular, kidney, nerve and brain systems. The Apelin/APJ system has multiple biological effects such as enhancing myocardial contractility, lowering blood pressure, promoting blood vessel growth, regulating insulin secretion, pituitary hormone release and body fluid balance. Apelin precursor peptide consists of 77 amino acid residues, which are then cleaved into fragments of different amino acid lengths, including: Apelin-12, Apelin-13, Apelin-17 and Apelin-36, etc. These peptides can be produced by peptide synthesis . Studies have shown that Apelin-17 can promote platelet aggregation and promote in vitro thrombosis, while APJ receptor blocker F13A inhibits Apelin-17-induced platelet aggregation and in vitro thrombosis. In addition, Apelin-17 has a synergistic platelet activator thrombin-induced platelet aggregation.
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