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Basic Info
CAS Number
5508-58-7
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Product Description
- Cat. #: AKI-05
- Product: Andrographolide
- CAS No.: 5508-58-7
- Molecular Formula: C20H30O5
- Molecular Weight: 350.4492
- Plant Source: andrographis paniculata
- Part Used: Leaves
- Specification: 99%min
- Availability: In stock
- Biological Activity: antiinflammatory, immunosuppressant and neuroprotective
AI Product Description
*The following content is generated by AI and is for reference only.
Andrographolide is a bioactive diterpenoid lactone isolated primarily from the aerial parts of *Andrographis paniculata*, a medicinal herb widely used in traditional Asian medicine. With the chemical formula C20H30O5 and the CAS Registry Number 54724-19-7, this compound features a unique labdane-type skeleton containing an α-methylene-γ-butyrolactone moiety, which is crucial for its biological activity. It typically appears as a white to off-white crystalline powder, exhibiting high stability under standard storage conditions while maintaining potent pharmacological properties.
The primary applications of Andrographolide span diverse therapeutic areas, driven by its extensive anti-inflammatory, antiviral, and immunomodulatory effects. Clinically, it has been investigated for treating upper respiratory tract infections, including the common cold and influenza, due to its ability to inhibit viral replication and modulate cytokine production. Beyond infectious diseases, research highlights its potential in managing chronic inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease by suppressing pro-inflammatory pathways like NF-κB. Furthermore, emerging studies suggest significant anticancer properties, where Andrographolide demonstrates the capacity to induce apoptosis in various tumor cell lines, including those of breast, lung, and colon cancers, often through the regulation of cell cycle progression.
In the pharmaceutical industry, Andrographolide serves as a lead compound for drug development targeting oxidative stress and metabolic disorders. Its safety profile is generally favorable, though clinical trials continue to optimize dosage regimens for specific indications. As a natural product with a well-documented historical use, it bridges traditional herbal knowledge with modern scientific validation. Researchers are currently exploring its formulation into novel delivery systems to enhance bioavailability, given its moderate water solubility. Overall, Andrographolide represents a promising candidate in integrative medicine, offering a multifaceted approach to treating complex diseases while minimizing adverse effects associated with synthetic alternatives. Continued investigation into its molecular mechanisms promises to unlock new therapeutic strategies for global health challenges.
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