Adrenomedullin (Adrenomedullin, ADM) is a peptide with multiple biological activities, widely involved in body activities. Studies have shown that it plays an important role in the formation of new blood vessels. The current research on adrenomedullin mainly focuses on tumors, and the latest research shows that Adrenomedullin (22-52) (human) also has a certain inhibitory effect on human retinal capillary endothelial cells induced by high glucose. Adrenomedullin (22-52) (human) is composed of 31 amino acids and is a fragment of Adrenomedulli without Cys. From the perspective of peptide synthesis, such a sequence has a more stable production process.