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Other Specialized Reagents

6-Chloropyridine-2-Carboxylic Acid

Category:

Other Specialized Reagents

CAS NO:

4684-94-0

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

4684-94-0

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

6-Chloropyridine-2-carboxylic acid is a versatile heterocyclic building block widely utilized in the pharmaceutical and agrochemical industries. With the molecular formula C₆H₄ClNO₂ and a CAS registry number of 1079-45-8, this compound features a pyridine ring substituted with a chlorine atom at the sixth position and a carboxylic acid group at the second position. The unique electronic properties of the pyridine nitrogen, combined with the reactive chloro substituent, make it an ideal precursor for diverse synthetic transformations. The primary application of 6-chloropyridine-2-carboxylic acid lies in the development of novel bioactive molecules. It serves as a critical intermediate in the synthesis of various drugs targeting central nervous system disorders, anti-inflammatory agents, and kinase inhibitors. The presence of the chlorine atom allows for facile nucleophilic substitution reactions, enabling chemists to introduce amine, thiol, or alkoxy groups to generate complex derivatives with enhanced biological activity. Furthermore, the carboxylic acid functionality provides a handle for amide bond formation, facilitating coupling reactions with amines to create peptidomimetics or specific ligand structures. In the agricultural sector, this compound contributes to the production of herbicides and fungicides designed to improve crop yield and protect against pathogens. Its structural stability under varying environmental conditions makes it suitable for formulating effective agrochemical products. Additionally, researchers employ this molecule in materials science to develop functional organic polymers and metal-organic frameworks (MOFs) due to its ability to coordinate with metal centers through both the nitrogen and oxygen atoms. Synthetically, the compound can be prepared via the oxidation of corresponding methyl precursors or through direct carboxylation of 6-chloropyridine derivatives. High-purity grades are essential for ensuring consistent reaction outcomes in large-scale manufacturing processes. As the demand for efficient, selective catalysts and advanced therapeutic agents grows, the role of 6-chloropyridine-2-carboxylic acid as a fundamental scaffold in medicinal chemistry remains indispensable. Its availability from major chemical suppliers ensures accessibility for academic research and industrial scale-up, supporting ongoing innovation in drug discovery and material engineering sectors globally.