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Other Specialized Reagents

5-Bromo-2-Methoxypyridine

Category:

Other Specialized Reagents

CAS NO:

13472-85-0

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

13472-85-0

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

5-Bromo-2-Methoxypyridine is a versatile heterocyclic building block widely utilized in organic synthesis and pharmaceutical research. With the chemical formula C6H6BrNO and a CAS registry number of 3198-40-7, this compound features a pyridine ring substituted with a methoxy group at the second position and a bromine atom at the fifth position. The presence of these functional groups imparts unique reactivity patterns, making it an essential intermediate for constructing complex molecular architectures. The primary application of 5-Bromo-2-Methoxypyridine lies in cross-coupling reactions, particularly palladium-catalyzed processes such as Suzuki-Miyaura, Heck, and Sonogashira couplings. These reactions allow chemists to efficiently attach various carbon-based fragments to the pyridine scaffold, facilitating the creation of biologically active compounds. Due to its structural similarity to many natural alkaloids and bioactive molecules, this reagent serves as a critical precursor in the development of novel drugs targeting oncology, infectious diseases, and neurological disorders. In agrochemical research, derivatives synthesized from this starting material are investigated for their potential as herbicides or fungicides, offering improved efficacy and environmental profiles compared to older generations of pesticides. Furthermore, the compound finds utility in materials science, where it contributes to the synthesis of luminescent dyes and organic semiconductors. The electron-withdrawing nature of the bromine atom combined with the electron-donating methoxy group creates a specific electronic environment that enhances nucleophilic substitution capabilities while maintaining ring stability under diverse reaction conditions. Handling this substance requires standard laboratory safety precautions, as halogenated aromatic compounds can be irritating to skin and eyes. It is typically stored in cool, dry environments away from incompatible oxidizers to prevent degradation. As the demand for efficient synthetic routes to nitrogen-containing heterocycles grows, 5-Bromo-2-Methoxypyridine remains a cornerstone reagent in medicinal chemistry laboratories worldwide. Its availability in high purity grades ensures reliable performance in both academic investigations and industrial-scale manufacturing processes, supporting continuous innovation in drug discovery and advanced material development.