Category:
Biochemistry Reagent
CAS NO:
9002-18-0
Standard:
N;
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Basic Info
CAS Number
9002-18-0
Pharmacopoeia
N;
Grade
Food Grade
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
NA
Minimum Order Quantity
1kg
Delivery Cycle
10-30days
Product Description
|
Purity(HPLC) |
≥90% |
|
Substitution(1H-NMR) |
≥90% |
|
Identity |
Conforms to structure(1H-NMR) |
|
Foreign material |
None |
|
Molecular weight (Mn) |
10000±1000Da |
|
Polydiispersity (GPC) |
≤1.05 |
|
Appearance |
White to light-yellow powder |
AI Product Description
*The following content is generated by AI and is for reference only.
4-arm PEG Maleimide, also known as 4-arm PEG MAL, is a highly versatile heterobifunctional polymer reagent widely utilized in bioconjugation and drug delivery research. Chemically, it consists of a central core with four polyethylene glycol (PEG) chains radiating outward, each terminating in a reactive maleimide group. While the exact molecular formula varies slightly depending on the specific molecular weight of the PEG chain (commonly ranging from 2k to 20k Daltons per arm), the general structural representation often corresponds to CₓHᵧN₂Oₙ, where x, y, and n depend on the average degree of polymerization. The Compound Abstract Service does not assign a single universal CAS number to all variants; instead, specific CAS numbers are allocated based on the precise molecular weight and purity grade, such as those found in catalogs for 10k or 20k Dalton versions.
The primary utility of this reagent lies in its ability to form stable thioether bonds with sulfhydryl groups (-SH) present on proteins, peptides, antibodies, and other biomolecules containing cysteine residues. This reaction occurs rapidly under mild physiological conditions without affecting most other functional groups, making it ideal for site-specific labeling. In therapeutic contexts, 4-arm PEG Maleimide is frequently employed to extend the circulation half-life of protein drugs through PEGylation, thereby reducing immunogenicity and improving pharmacokinetic profiles. Furthermore, its tetra-functional architecture allows for the construction of complex branched nanostructures, dendrimers, and hydrogels. Researchers utilize this molecule to link two distinct biological entities, create antibody-drug conjugates (ADCs), or modify surfaces for biosensor applications. Its water solubility and biocompatibility ensure minimal toxicity, cementing its status as a cornerstone material in modern chemical biology and pharmaceutical development for creating advanced, targeted therapeutics and diagnostic tools.
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