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Other Specialized Reagents

4- Fluoro Toluene

Category:

Other Specialized Reagents

CAS NO:

352-32-9

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

352-32-9

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

4-Fluorotoluene, also known as p-fluorotoluene or 1-methyl-4-fluorobenzene, is a vital aromatic compound widely utilized in the pharmaceutical and agrochemical industries. Its chemical formula is C7H7F, and it carries the CAS Registry Number 459-32-1. Structurally, this molecule consists of a benzene ring substituted with a methyl group at the first position and a fluorine atom at the fourth position. This specific arrangement imparts unique physicochemical properties that make it an indispensable building block for complex organic synthesis. The primary application of 4-fluorotoluene lies in its role as a key intermediate in the production of active pharmaceutical ingredients (APIs). The introduction of a fluorine atom into organic structures often enhances metabolic stability, lipophilicity, and binding affinity to biological targets. Consequently, derivatives synthesized from 4-fluorotoluene are frequently found in non-steroidal anti-inflammatory drugs (NSAIDs), antidepressants, and various cardiovascular medications. In the agricultural sector, this compound serves as a precursor for developing high-efficiency herbicides and pesticides, where the fluorinated moiety contributes to improved environmental persistence and efficacy against specific pests. Beyond these major sectors, 4-fluorotoluene is employed in the synthesis of liquid crystals and advanced materials used in display technologies. The presence of both electron-donating and electron-withdrawing groups on the aromatic ring facilitates diverse electrophilic substitution reactions, allowing chemists to introduce further functional groups with high precision. It is typically produced via the direct fluorination of toluene or through halogen exchange reactions involving other fluoroarenes. Due to its volatility and potential irritant properties, handling requires standard safety precautions, including adequate ventilation and personal protective equipment. Despite these considerations, its versatility ensures continued demand in global chemical supply chains. As research advances in medicinal chemistry, the utility of 4-fluorotoluene is expected to expand, supporting the development of next-generation therapeutics and sustainable agricultural solutions. Its strategic position in synthetic pathways underscores its importance in modern industrial chemistry.