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Other Specialized Reagents

3-Bromo-5-Fluoropyridine

Category:

Other Specialized Reagents

CAS NO:

407-20-5

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

407-20-5

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

3-Bromo-5-fluoropyridine is a versatile heterocyclic building block widely utilized in modern medicinal chemistry and materials science. With the molecular formula C5H3BrFN and CAS Registry Number 1204-97-3, this compound features a pyridine ring substituted with a bromine atom at the third position and a fluorine atom at the fifth position. The presence of both halogen substituents significantly enhances its reactivity profile, making it an ideal precursor for palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura, Stille, and Buchwald-Hartwig aminations. These transformations allow chemists to efficiently construct complex biaryl structures, which are fundamental motifs in numerous bioactive pharmaceutical agents. The primary application of 3-bromo-5-fluoropyridine lies in the synthesis of kinase inhibitors, antidepressants, and anti-inflammatory drugs. The fluorine atom often improves the metabolic stability and lipophilicity of drug candidates, while the bromine site serves as a strategic handle for further functionalization. Consequently, this molecule plays a critical role in fragment-based drug discovery and lead optimization processes within the pharmaceutical industry. Beyond medicine, it is also employed in the development of organic light-emitting diodes (OLEDs) and advanced liquid crystal materials due to its unique electronic properties and rigid planar structure. Commercially available from major chemical suppliers, high-purity grades of 3-bromo-5-fluoropyridine are essential for research laboratories conducting synthetic methodology development. Its relatively low cost compared to other specialized heterocycles makes it accessible for large-scale pilot studies. However, handling requires standard safety precautions, including the use of personal protective equipment, as it may be irritating to skin and eyes. Overall, 3-bromo-5-fluoropyridine stands out as a pivotal intermediate that bridges simple starting materials with sophisticated functional molecules, driving innovation across multiple scientific disciplines. Researchers continue to explore its potential in novel catalytic systems and sustainable synthesis pathways, ensuring its relevance in future chemical advancements.