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Other Specialized Reagents

2,2,2-Trifluoroacetamide

Category:

Other Specialized Reagents

CAS NO:

354-38-1

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

354-38-1

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

2,2,2-Trifluoroacetamide is a specialized organic compound characterized by the presence of a trifluoromethyl group attached to an amide functionality. Its molecular formula is C₂H₂F₃NO, and it carries the CAS registry number 453-19-8. This white to off-white crystalline solid is highly soluble in water and common polar organic solvents, making it versatile for various chemical applications. The unique electron-withdrawing nature of the trifluoromethyl moiety significantly alters the reactivity of the amide nitrogen compared to standard acetamides, enhancing its utility as a building block in medicinal chemistry and materials science. Primarily utilized as a synthetic intermediate, 2,2,2-trifluoroacetamide serves as a crucial precursor in the production of pharmaceutical agents. It is frequently employed in the synthesis of fluorinated heterocycles, which are integral components of many modern drugs targeting oncology, antiviral treatments, and anti-inflammatory pathways. The introduction of the trifluoromethyl group often improves the metabolic stability, lipophilicity, and bioavailability of drug candidates, thereby optimizing their therapeutic efficacy. Furthermore, this compound finds application in the development of agrochemicals, where it aids in creating more effective herbicides and pesticides with reduced environmental persistence. In the realm of materials research, 2,2,2-trifluoroacetamide contributes to the formulation of advanced polymers and liquid crystals. Its ability to participate in condensation reactions allows for the creation of novel polyamides with enhanced thermal resistance and mechanical strength, suitable for high-performance engineering plastics. Additionally, researchers utilize it in organocatalysis and as a protecting group strategy in complex molecule synthesis. While generally stable under standard conditions, care must be taken during handling due to potential hydrolysis into trifluoroacetic acid and ammonia under acidic or basic environments. Safety data sheets recommend standard laboratory precautions, including the use of gloves and eye protection, to prevent skin irritation or inhalation risks. As the demand for fluorinated compounds grows across industries ranging from fine chemicals to nanotechnology, 2,2,2-trifluoroacetamide remains a pivotal reagent driving innovation in molecular design and functional material development.