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Other Specialized Reagents

2-Fluoro-5-Formylbenzonitrile

Category:

Other Specialized Reagents

CAS NO:

218301-22-5

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

218301-22-5

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

2-Fluoro-5-formylbenzonitrile is a specialized organic intermediate widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic compounds. With the Chemical Abstracts Service (CAS) Registry Number 136047-98-4, this compound features a benzene ring substituted with three distinct functional groups: a fluoro atom at the second position, a formyl group at the fifth position, and a nitrile group adjacent to the fluorine. Its molecular formula is C₈H₄FNO, corresponding to a molar mass of approximately 149.12 g/mol. The presence of these diverse reactive sites makes it an exceptionally versatile building block for medicinal chemists seeking to construct bioactive scaffolds. The primary application of 2-fluoro-5-formylbenzonitrile lies in the development of novel drug candidates. The aldehyde moiety allows for nucleophilic additions, condensation reactions, and reductive aminations, facilitating the formation of imines, oximes, and various heterocycles such as pyridines and quinolines. Simultaneously, the nitrile group serves as a precursor for amides, carboxylic acids, or tetrazoles through hydrolysis or cycloaddition reactions. The fluorine substituent is particularly valuable in modern drug design due to its ability to modulate metabolic stability, lipophilicity, and binding affinity within biological targets. By introducing fluorine into the aromatic core, researchers can often enhance the pharmacokinetic profile of lead compounds while maintaining structural integrity. In the agrochemical sector, this intermediate is employed in the synthesis of fungicides and herbicides where specific electronic properties are required for optimal activity against pests. Its high purity and stability under standard storage conditions make it suitable for large-scale industrial processes, provided appropriate safety measures are observed regarding potential toxicity and environmental release. Researchers frequently utilize this molecule in combinatorial chemistry libraries to rapidly generate diverse analogs for structure-activity relationship (SAR) studies. As the demand for precision medicine grows, derivatives of 2-fluoro-5-formylbenzonitrile continue to play a pivotal role in advancing therapeutic agents that target oncology, infectious diseases, and inflammatory conditions. Consequently, it remains a critical component in the toolkit of synthetic organic chemists aiming to create next-generation chemical entities with superior efficacy and safety profiles.