Product Description
AI Product Description
*The following content is generated by AI and is for reference only.
2-Fluoro-4-methylaniline, chemically known as 1-amino-2-fluoro-4-methylbenzene, is a specialized organic intermediate widely utilized in the pharmaceutical and agrochemical industries. With the molecular formula C7H8FN and a molecular weight of approximately 125.14 g/mol, this compound features an aromatic benzene ring substituted with a methyl group at the para position and a fluorine atom at the ortho position relative to the amino group. Its primary CAS Registry Number is 396-16-5, which serves as its unique identifier for chemical databases and regulatory compliance worldwide. The presence of both the electron-donating methyl group and the electronegative fluorine atom significantly influences the electronic density of the ring, making it highly reactive toward electrophilic substitution and nucleophilic aromatic displacement reactions. This unique reactivity profile renders it indispensable for synthesizing complex heterocyclic structures found in modern drug candidates.
In the pharmaceutical sector, 2-fluoro-4-methylaniline serves as a critical building block for developing kinase inhibitors, antihistamines, and various central nervous system active agents. The fluorine substituent often enhances metabolic stability and lipophilicity, improving the pharmacokinetic properties of final drug molecules. Similarly, in agriculture, derivatives synthesized from this amine are employed in the production of herbicides and fungicides designed to protect crops against specific pathogens while minimizing environmental persistence. The compound typically appears as a colorless to pale yellow liquid or low-melting solid, possessing a characteristic amine odor. It is soluble in common organic solvents such as ethanol, ether, and chloroform but shows limited solubility in water. Safety protocols during handling require standard precautions for amines, including the use of personal protective equipment to prevent skin contact and inhalation, as it may be irritating to the respiratory tract and eyes. Global supply chains maintain strict quality controls to ensure high purity levels, usually exceeding 98%, to meet the rigorous demands of fine chemical synthesis. As research into novel therapeutic modalities expands, the demand for structurally diverse intermediates like 2-fluoro-4-methylaniline continues to grow, supporting innovation in medicinal chemistry and sustainable agricultural practices globally.