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Other Specialized Reagents

2-Chloro-5-Fluoropyridine

Category:

Other Specialized Reagents

CAS NO:

31301-51-6

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

31301-51-6

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

2-Chloro-5-fluoropyridine is a versatile heterocyclic building block widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex organic molecules. With the chemical formula C₅H₃ClFN and CAS Registry Number 387-10-4, this compound features a pyridine ring substituted with a chlorine atom at the second position and a fluorine atom at the fifth position. The presence of these two distinct halogen substituents imparts unique reactivity profiles, making it an ideal precursor for various cross-coupling reactions. The primary application of 2-chloro-5-fluoropyridine lies in medicinal chemistry, where it serves as a key intermediate in the development of novel drug candidates. Its structure allows for selective nucleophilic aromatic substitution, enabling chemists to introduce diverse functional groups at specific positions on the pyridine ring. This property is particularly valuable when synthesizing kinase inhibitors, antiviral agents, and other bioactive compounds that require precise structural modifications. Furthermore, the compound finds significant use in the production of agrochemicals, including herbicides and fungicides, where its stability and reactivity contribute to the efficacy of the final products. From a synthetic perspective, the molecule offers multiple pathways for transformation. The chlorine atom is generally more reactive towards palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings, allowing for the formation of carbon-carbon or carbon-nitrogen bonds. Meanwhile, the fluorine atom can be retained to modulate the lipophilicity and metabolic stability of the resulting derivatives. Due to its commercial availability and relatively low cost, 2-chloro-5-fluoropyridine has become a staple reagent in research laboratories focused on drug discovery and process chemistry. Safety protocols during handling are essential, as with most halogenated heterocycles. It should be stored in a cool, dry place away from incompatible materials, and appropriate personal protective equipment must be worn to prevent exposure. Overall, 2-chloro-5-fluoropyridine represents a crucial tool for modern organic synthesis, bridging the gap between simple starting materials and high-value therapeutic and agricultural applications through its exceptional chemical versatility.