Product Description
Pharmaceutical
Raw Materials and Intermediates
AI Product Description
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2-Chloro-4-Bromopyridine is a versatile heterocyclic building block widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex organic molecules. With the Chemical Abstracts Service (CAS) Registry Number 35971-66-5, this compound features a pyridine ring substituted with a chlorine atom at the second position and a bromine atom at the fourth position. Its molecular formula is C5H3BrClN, corresponding to a molar mass of approximately 198.44 g/mol. The molecule appears as a pale yellow to brownish liquid or low-melting solid, characterized by distinct halogenated reactivity patterns that make it highly valuable in cross-coupling reactions.
The primary application of 2-Chloro-4-Bromopyridine lies in its role as a key intermediate for constructing biologically active compounds. Due to the presence of two different halogen atoms, chemists can selectively functionalize specific positions on the pyridine ring through palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Stille, or Buchwald-Hartwig couplings. This selectivity allows for the precise introduction of various aryl, vinyl, or alkyl groups, facilitating the efficient synthesis of advanced drug candidates. It is frequently employed in the production of kinase inhibitors, anti-inflammatory agents, and antiviral therapeutics where the pyridine scaffold is essential for biological activity.
In the agricultural sector, this chemical serves as a precursor for developing novel pesticides and herbicides designed to enhance crop protection mechanisms. The unique electronic distribution within the molecule influences its reactivity, enabling the creation of diverse derivatives with optimized physicochemical properties. Researchers value this compound for its stability under standard storage conditions while maintaining high reactivity during synthetic transformations. However, handling requires appropriate safety measures due to potential irritation risks associated with halogenated aromatic compounds. Overall, 2-Chloro-4-Bromopyridine remains an indispensable tool in modern medicinal chemistry and materials science, driving innovation in the development of next-generation therapeutic and agronomic solutions. Its availability from major chemical suppliers ensures steady supply chains for global research and manufacturing facilities seeking to accelerate drug discovery pipelines.