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Other Specialized Reagents

2-Bromopyridien-4-Methanol

Category:

Other Specialized Reagents

CAS NO:

118289-16-0

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

118289-16-0

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

2-Bromopyridine-4-methanol is a specialized organic intermediate widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic compounds. With the molecular formula C6H6BrNO and a CAS number of 137598-07-7, this compound features a pyridine ring substituted with both a bromine atom at the second position and a hydroxymethyl group at the fourth position. This unique structural arrangement makes it an invaluable building block for medicinal chemists seeking to construct bioactive scaffolds containing nitrogen-containing rings. The primary application of 2-bromopyridine-4-methanol lies in its role as a versatile precursor for cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira couplings. The presence of the reactive bromine atom allows for efficient substitution with various boronic acids, alkynes, or amines, facilitating the rapid assembly of diverse molecular architectures. Furthermore, the hydroxymethyl group offers additional synthetic handles for oxidation to aldehydes or carboxylic acids, or for conversion into ethers and esters, thereby expanding its utility in multi-step synthesis pathways. In the pharmaceutical sector, derivatives synthesized from this intermediate are often investigated for their potential therapeutic properties, including anti-inflammatory, antimicrobial, and anticancer activities. The pyridine core is a common motif in many approved drugs, contributing to favorable pharmacokinetic profiles and receptor binding affinity. Consequently, researchers frequently employ 2-bromopyridine-4-methanol as a starting material to optimize lead compounds during drug discovery campaigns. In agrochemicals, similar structures are explored for developing novel pesticides and herbicides that target specific biological pathways in pests while minimizing environmental impact. Handling this chemical requires standard laboratory safety precautions due to its reactivity and potential irritant properties. It is typically stored in cool, dry conditions away from strong oxidizing agents to maintain stability. As demand for advanced heterocyclic intermediates grows, 2-bromopyridine-4-methanol remains a critical component in the toolkit of synthetic chemists aiming to develop next-generation active pharmaceutical ingredients and functional materials. Its balance of reactivity and stability ensures continued relevance in modern organic synthesis laboratories globally.