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Other Specialized Reagents

2-Bromo-5-Trifluoromethylpyridine

Category:

Other Specialized Reagents

CAS NO:

50488-42-1

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

50488-42-1

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

2-Bromo-5-trifluoromethylpyridine is a versatile heterocyclic building block widely utilized in modern organic synthesis and pharmaceutical research. With the molecular formula C6H3BrF3N and CAS Registry Number 140968-79-7, this compound features a pyridine ring substituted with a bromine atom at the second position and a trifluoromethyl group at the fifth position. The presence of these functional groups imparts unique reactivity patterns, making it an ideal precursor for various cross-coupling reactions such as Suzuki-Miyaura, Heck, and Sonogashira couplings. The primary application of 2-Bromo-5-trifluoromethylpyridine lies in the development of bioactive molecules. Pharmaceutical chemists frequently employ this reagent to construct complex heterocyclic scaffolds found in active pharmaceutical ingredients (APIs). The electron-withdrawing nature of the trifluoromethyl group enhances metabolic stability and lipophilicity, properties often desirable in drug design. Furthermore, the bromine atom serves as a strategic handle for introducing diverse side chains, enabling the fine-tuning of biological activity and pharmacokinetic profiles. Beyond medicinal chemistry, this compound finds utility in the agrochemical industry for synthesizing novel herbicides and fungicides. Its structural motif contributes to the creation of compounds with high efficacy against specific agricultural pests while maintaining environmental safety standards. Additionally, researchers in materials science explore its potential in developing advanced organic electronic materials, where the pyridine core facilitates charge transport properties. The commercial availability of 2-Bromo-5-trifluoromethylpyridine supports global R&D efforts across multiple sectors. High purity grades are typically required to ensure consistent reaction outcomes in sensitive synthetic pathways. As a key intermediate, it bridges the gap between simple starting materials and sophisticated functional molecules. Its role underscores the importance of halogenated heterocycles in accelerating the discovery pipeline for next-generation therapeutic agents and functional materials. Consequently, this chemical remains a staple reagent in laboratories dedicated to advancing chemical sciences and improving human health through innovative molecular design.