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Other Specialized Reagents

2-Bromo-3-Methoxypyridine

Category:

Other Specialized Reagents

CAS NO:

24100-18-3

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

24100-18-3

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

2-Bromo-3-Methoxypyridine is a versatile heterocyclic building block widely utilized in modern organic synthesis and medicinal chemistry. With the chemical formula C6H6BrNO and CAS Registry Number 104958-75-6, this compound features a pyridine ring substituted with a bromine atom at the second position and a methoxy group at the third position. The unique electronic properties of the pyridine nitrogen, combined with the electron-donating effect of the methoxy group and the reactive carbon-bromine bond, make it an ideal precursor for various cross-coupling reactions. Primarily, 2-Bromo-3-Methoxypyridine serves as a crucial intermediate in the production of pharmaceutical agents, agrochemicals, and advanced materials. Its reactivity allows chemists to efficiently introduce diverse functional groups via palladium-catalyzed coupling methodologies, such as Suzuki-Miyaura, Heck, and Sonogashira reactions. These transformations are essential for constructing complex molecular architectures found in bioactive compounds, including kinase inhibitors, antiviral drugs, and anti-inflammatory agents. Furthermore, the methoxy substituent can be selectively demethylated or modified to yield further derivatives, enhancing its utility in structure-activity relationship (SAR) studies during drug discovery campaigns. In the agricultural sector, this molecule contributes to the development of novel pesticides and herbicides designed to target specific biological pathways with high efficacy and minimal environmental impact. The presence of the bromine atom facilitates subsequent nucleophilic substitutions, enabling the synthesis of pyridine-based heterocycles that mimic natural products or possess enhanced metabolic stability. Additionally, researchers employ this reagent in the synthesis of fluorescent probes and ligands for coordination chemistry applications. Due to its commercial availability and high purity grades, 2-Bromo-3-Methoxypyridine remains a staple in laboratory settings worldwide. It is typically stored under inert atmospheres at low temperatures to prevent decomposition, ensuring optimal performance in sensitive synthetic protocols. As the demand for efficient, modular synthesis strategies grows, this compound continues to play a pivotal role in accelerating the development of next-generation chemical solutions across multiple scientific disciplines.