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Other Specialized Reagents

2-Amino-5-Iodopyridine

Category:

Other Specialized Reagents

CAS NO:

20511-12-0

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

20511-12-0

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

2-Amino-5-Iodopyridine is a specialized heterocyclic compound widely utilized in modern organic synthesis and medicinal chemistry. With the molecular formula C₅H₅IN₂ and a CAS Registry Number of 104697-83-6, this pale yellow to off-white crystalline solid serves as a critical building block for constructing complex nitrogen-containing architectures. Its structure features a pyridine ring substituted with an amino group at the second position and a heavy iodine atom at the fifth position, creating a versatile platform for further chemical modification. The primary utility of 2-Amino-5-Iodopyridine lies in its ability to participate in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig couplings. The carbon-iodine bond is relatively labile, allowing for efficient substitution with various nucleophiles or organometallic reagents under mild conditions. This reactivity makes it indispensable for synthesizing advanced pharmaceutical intermediates, agrochemicals, and functional materials. Researchers frequently employ this molecule to introduce specific substituents onto the pyridine scaffold, thereby tuning the electronic and steric properties of the final drug candidates. In the pharmaceutical sector, derivatives of 2-Amino-5-Iodopyridine are often found in kinase inhibitors, anticancer agents, and antiviral drugs. The presence of the amino group facilitates hydrogen bonding interactions with biological targets, while the iodine atom can be strategically replaced to optimize pharmacokinetic profiles. Furthermore, the compound acts as a precursor for fluorescent probes and luminescent materials used in analytical chemistry and imaging technologies. Due to the high cost of iodinated precursors, suppliers emphasize high purity standards, typically exceeding 98%, to ensure reproducible reaction outcomes in multi-step syntheses. Handling this substance requires standard laboratory safety precautions, including the use of personal protective equipment, as it may be irritating to skin and eyes. It should be stored in a cool, dry place away from light and moisture to prevent degradation. As demand grows for novel therapeutics targeting difficult protein-protein interactions, the role of 2-Amino-5-Iodopyridine as a strategic intermediate continues to expand within the global chemical supply chain, bridging fundamental research and industrial application.