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Other Specialized Reagents

2-Amino-5-Bromopyridine

Category:

Other Specialized Reagents

CAS NO:

1072-97-5

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

1072-97-5

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

2-Amino-5-bromopyridine is a versatile heterocyclic building block widely utilized in the fields of medicinal chemistry, agrochemical research, and materials science. With the molecular formula C₅H₅BrN₂ and a CAS registry number of 1073-84-9, this compound features a pyridine ring substituted with an amino group at the second position and a bromine atom at the fifth position. This specific substitution pattern imparts unique electronic properties, making it an ideal precursor for synthesizing complex nitrogen-containing heterocycles. The primary application of 2-amino-5-bromopyridine lies in its role as a key intermediate for pharmaceutical development. The presence of both nucleophilic amine and electrophilic bromine sites allows for diverse chemical transformations, including palladium-catalyzed cross-coupling reactions such as Suzuki, Heck, and Sonogashira couplings. These reactions are instrumental in constructing biologically active scaffolds like kinase inhibitors, anti-inflammatory agents, and antiviral compounds. Furthermore, the molecule serves as a foundational structure for creating ligands used in coordination chemistry and the synthesis of fluorescent probes or organic semiconductors. In the agrochemical sector, derivatives of this compound are investigated for their potential as herbicides and fungicides, offering improved efficacy and selectivity compared to older generations of pesticides. Its structural versatility enables chemists to fine-tune biological activity by modifying the substituents on the aromatic ring without altering the core heterocyclic system. From a safety perspective, while generally stable under standard conditions, it should be handled with appropriate personal protective equipment due to potential irritancy and toxicity associated with halogenated amines. Storage recommendations typically involve keeping the substance in a cool, dry place away from strong oxidizers and moisture to prevent degradation. As global demand for novel therapeutic agents grows, 2-amino-5-bromopyridine remains a critical commodity in the synthetic toolkit of modern chemical laboratories, facilitating the efficient production of high-value molecules across multiple industries.