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<h3>Overview</h3>
<p><strong>13-cis-Retinoic Acid-d5</strong> is a deuterated internal standard for LC-MS/MS quantification of isotretinoin. Synthesized via catalytic hydrogenation and isotopic exchange, its molecular formula is C20H24D5O and CAS number is 1369870-88-1.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical Analysis:</strong> Used as a reference standard in bioequivalence studies for acne therapeutics.</li>
<li><strong>Metabolomics:</strong> Enables precise tracking of retinoid metabolic pathways in clinical samples.</li>
<li><strong>Quality Control:</strong> Validates assay accuracy in bulk drug substance manufacturing.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly store under inert atmosphere at -20°C to prevent oxidation. Handle with PPE due to potential teratogenicity risks associated with retinoid analogs during synthesis and analysis.</p>