Product Name: 1,3-bi-TBS-trans-Calcitriol
CAS No.: 140710-98-1
Quality Standard: Enterprise standard, content NLT 99%
Main Application: Synthesis of Calcitriol
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>1,3-bi-TBS-trans-Calcitriol</strong> is a protected synthetic intermediate for vitamin D analogs. The molecule features bis-tert-butyldimethylsilyl protection on the 1 and 3 hydroxyl groups of trans-calcitriol to facilitate multi-step synthesis.</p>
<ul>
<li><strong>Molecular Formula:</strong> C<sub>32</sub>H<sub>58</sub>O<sub>4</sub>Si<sub>2</sub></li>
<li><strong>CAS No:</strong> Not publicly indexed in standard registries</li>
</ul>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical R&D:</strong> Serves as a key precursor for synthesizing novel non-natural calcitriol derivatives with enhanced receptor affinity.</li>
<li><strong>Medicinal Chemistry:</strong> Utilized in structure-activity relationship (SAR) studies to optimize bone mineralization properties.</li>
<li><strong>Process Development:</strong> Employed in scale-up protocols for creating stable, high-purity active pharmaceutical ingredients.</li>
</ul>
<h3>Precautions</h3>
<p>Store under inert atmosphere at -20°C to prevent desilylation. Handle with appropriate PPE; avoid direct contact due to potential skin irritation. Strictly regulated for research use only, not for clinical administration.</p>