Verge Genomics has successfully seized the immense opportunities from AI and machine learning algorithms to revolutionise drug discovery processes for the largely unmet medical need of neurodegenerative diseases such as Parkinson’s. CEO Alice Zhang explains how the platform works, why she believes it is superior to traditional approaches and the company’s plans for the future.
Artificial Intelligence (AI) and machine learning has begun to dominate innovation in the medical field with the help of an increasing quantity and quality of data. For example, it has transformed diagnosis of complex diseases, the efficiency of medical devices, such as prosthetic limbs, and improved communication between patients and medical professionals.
Now, US-based start-up Verge Genomics has applied AI algorithms to the drug discovery process. The company’s revolutionary approach relies upon the large datasets it has collected from deceased patients with neurodegenerative diseases. Using this strategy they have successfully produced two possible drug candidates so far.
To support its innovative approach and its pipeline, Verge recently secured $32m in early venture capital financing from a mixture of technology firms and life sciences companies, bringing the company’s total funding since its foundation in 2015 to $36m.
Improving drug discovery using AI
Verge was co-founded by Alice Zhang, who is now its CEO, following her realisation while studying for her PHD that the ‘the way pharma companies discover drugs – using brute force and guesswork – was broken’.
Instead Verge applies learning AI algorithms to its large all-human genomic datasets to move drug discovery from the laboratory to the computer. Zhang said: "By using computational analysis on human genomic data, I discovered that drug discovery could be made both more effective and more efficient."
"By using both the front-end (machine learning) and the back-end infrastructure (experimental biology), we can rapidly test computational predictions in the lab and generate an enormous amount of proprietary, validation data that retrains our models and improves our algorithms at unprecedented scale and speed," Zhang explains.
One of the main challenges facing medical companies seeking to use AI to improve their systems or their products is that these types of algorithm rely upon large quantities of high quality data.
However, "at Verge, we’ve addressed this problem by generating our own data to create a data advantage that reinforces its algorithmic advantage," according to Zhang.
The use all-human data also means that, unlike standard clinical trials that rely on animal data, Verge uses human data from the beginning of its drug discovery process.
Focusing on discovering drugs for neurodegenerative diseases
Verge AI-based drug discovery approach currently focuses on neurodegenerative diseases, including Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS).
This is because Zhang believes that pharmaceutical companies’ flawed approach to drug discovery ‘has completely stalled for more complex brain diseases’, thereby making neurodegeneration one of the world’s greatest unmet medical needs.
The main reason why traditional drug discovery techniques have struggled to create treatments for neurodegenerative diseases is that they often focus on single genes, whereas ALS, Alzheimer’s and Parkinson’s are caused by the interactions between hundreds of genes.
Zhang said: "Our decision to focus on neurodegenerative disorders comes from where we saw the biggest need within the industry and could create the biggest impact.
"Our machine learning approach is best suited for complex, multi-gene diseases."
Verge’s genomic database, which was created in partnership with many academic and research centres, is composed of brain tissue samples from ALS and Parkinson’s patients who have passed away.
Zhang highlighted the importance of collaborations in accumulating one of the most comprehensive data sources for ALS: "The partnerships we have formed have been vitally important to the development of our proprietary compounds because they have been instrumental to providing the first building blocks to the proc...
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