The rapid development of an effective and safe vaccine against SARS-CoV-2 is a top priority for Swiss Rockets AG. A Basel-based subsidiary, RocketVax AG, was founded to utilize innovative Swiss technologies and expertise to achieve this goal.
"The development of a SARS-CoV-2 vaccine might be more complex than anticipated, and the first generation of vaccines may not provide the long-lasting, high-level protection that will be needed to end the many negative consequences of the global SARS-CoV-2 pandemic. A number of leading SARS-CoV-2 vaccine candidates use other viruses, such as adenoviruses tagged with just one coronavirus protein, particularly the spike protein which is required for the virus to enter cells. However, it is unlikely that these vaccines will induce strong and lasting protection against SARS-CoV-2. We believe that it is important to develop vaccines that cover as many SARS-CoV-2 proteins as possible but without any pathogenic potential", says Dr. Vladimir Cmiljanovic, Chairman and CEO of Swiss Rockets.
Prof. Dr. Thomas Klimkait, Virologist at the University of Basel and Project Leader of Preclinical Development at RocketVax, explains: "As an innovative next-generation vaccine, RocketVax is developing a complete but 'replication blocked' SARS-CoV-2 virus that presents all essential protein components in the virus particle to the human immune system." Novel methods are being utilized in the production of the active ingredient. RocketVax, in a first step, relies on ground-breaking DNA synthesis technology from the ETH spin-off Gigabases Switzerland AG. The gene sequence of the desired artificial viral genome, optimal for an immune response, is designed using high computing power and advanced DNA design algorithms. The designed genome lacks one essential virus element needed for replication. This element is provided by a human producer cell, yielding complete virus particles in the laboratory. The "artificial virus" can be made in large quantities for use as a vaccine. This technology allows the rapid production of various genome sequences, enabling vaccine production with one or mixtures of viral sequences. It also allows for incorporation of any relevant SARS-CoV-2 mutations that may arise in the future.
Foundation of RocketVax AG and acquisition of the inventor rights from the ETH spin-off Gigabases Switzerland AG
Swiss Rockets has acquired the exclusive rights to develop a SARS-CoV-2 vaccine using the breakthrough DNA synthesis technology from the ETH spin-off Gigabases Switzerland AG. The next generation of SARS-CoV-2 virus vaccines will be developed together with Gigabases and a consortium of experts from several leading Swiss universities and institutes.
For this purpose, Swiss Rockets has founded RocketVax AG in Basel and provides the necessary infrastructure with office and laboratory space as an incubator in cooperation with the Canton of Basel-City and the University of Basel. This provides RocketVax with access to the necessary biosafety laboratory. Swiss Rockets also acts as an accelerator by investing additional funds in the development of RocketVax in the medium term and is responsible for supporting RocketVax in national and international financing rounds. Also, management expertise is provided by Swiss Rockets, together with leading Swiss and international experts.
RocketVax works together with leading scientists
Prof. Marcel Tanner, Emeritus Professor of Epidemiology, Medical Parasitology and Public Health and former Director of the Swiss Tropical and Public Health Institute, will act as a chief scientific advisor. He is a leading clinical epidemiologist and a pioneer in R&D for vaccines and drugs against diseases of poverty and neglected tropical diseases.
Prof. Claudia Daubenberger, Head of Clinical Immunology at the Swiss Tropical and Public Health Institute, will support the clinical development. RocketVax will have access to an international clinical trial network to enable innovative and rapid clinical development in different human populations.
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