Extending its patient-centric BD Intevia™ Disposable Autoinjector platform, BD builds on past successes while meeting the requirements of new, highly viscous, high-volume biologics for chronic diseases
Multi-disciplinary teams at BD set out to develop an autoinjector platform ready to meet the requirements of the highly viscous, high-volume biologics that are upcoming in the chronic disease space. The result is an autoinjector platform that delivers an enhanced experience for patients , extends the design space beyond traditional subcutaneous (SC) delivery for biologics and can lower development risks for biopharmaceutical partners.
Large molecules
The market for monoclonal antibody-based drugs (mAbs) has undergone significant growth. These drugs are often characterised by large molecules requiring administration in large injection volumes and/or high concentrations. These proteins require parenteral administration via intravenous or SC injection, due to their low bioavailability via other routes. This can present a challenge for existing SC autoinjector technologies that have been limited to lower viscosities and volumes.
With the launch of the BD Intevia™ disposable autoinjector platform, BD offers a range of devices combining an autoinjector and a prefillable syringe in one integrated system specifically designed for high-viscosity, high-volume biologics. Created using BD’s quality-by-design approach, the BD Intevia™ 2.25 mL disposable autoinjector is a robust and integrated two-step, push-on-skin device that serves a broad design space, providing pharmaceutical companies with additional degrees of freedom and flexibility in drug formulation. The BD Intevia™ 2.25 mL disposable autoinjector delivers drugs with viscosities up to 40 cP safely and effectively. Pharmaceutical companies can adapt the BD Intevia™ 2.25 mL disposable autoinjector to deliver a range of drug volumes and viscosities without any need for customisation of the system or of its components.
8 mm needle technology
The BD Intevia™ 2.25 mL disposable autoinjector integrates the BD Neopak™ XtraFlow™ 2.25 mL glass prefillable syringe, featuring innovative 8 mm needles with Thin Wall (TW) cannula technology . BD Neopak™ XtraFlow™ glass prefillable syringes are characterised by breakage resistance, design quality, autoinjector compatibility and dimensional precision for dose accuracy. By directly addressing many of the risk factors that can cause development delays, BD Neopak™ XtraFlow™ glass prefillable syringes contribute to reduced time to market and optimised commercialisation of biopharmaceuticals.
The BD Neopak™ XtraFlow™ glass prefillable syringe simplifies the burden of device integration faced by pharmaceutical companies. With its robust integration into the BD Intevia™ disposable autoinjector platform, the BD Neopak™ XtraFlow™ glass prefillable syringe helps eliminate the risks associated with the integration of components from diverse manufacturers, as well as the risks associated with the customisation of the secondary device.
The integration of the BD Neopak™ XtraFlow™ glass prefillable syringe supports simpler adaptation to drug volumes and viscosities and reliable combination product performance. This may contribute to cost savings for biopharmaceutical partners, while also contributing to comfort, safety and convenience for patients.
Customization not required
With BD Intevia™ disposable autoinjectors, one device configuration addresses a broad range of viscosities and volumes without the need to customise system and subsystem components. This high degree of flexibility is made possible by accommodating the demands of different viscosities and volumes solely through the parameters of the needle integrated into the Neopak™ XtraFlow™ glass prefillable syringe. By using a shorter needle and increa...
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