
Secondly, the distribution of the top 10 types of biological drugs is shown in Fig. 2.

近10年全球上市生物药类型TOP10分布 | Distribution of Top 10 Types of Global Biological Drugs Marketed in Recent Decade |
数量 | Quantity |
疫苗制剂 | Vaccine formulation |
完整抗体 | Complete antibody |
重组细胞因子 | Recombinant cytokine |
血液提取物 | Blood extract |
重组生物酶 | Recombinant biological enzyme |
重组激素 | Recombinant hormone |
融合蛋白 | Fusion protein |
重组凝血因子 | Recombinant coagulation factor |
细胞疗法 | Cell therapy |
重组多肽 | Recombinant polypeptide |
Research and marketed varieties of antibody drugs have been hot in recent years, however, vaccine formulations have been the biological drug with the largest quantity marketed in recent decade in the world. New vaccines are one of the key fields of the biomedicine industry in China, and the frequent negative vaccine events have raised higher requirements for vaccine development and manufacturing enterprises. The cervical cancer vaccine marketed overseas has eventually been marketed in China, however, it is still an imported drug. We look forward to the rapid strengthening of R&D of Chinese-produced vaccines, to break the monopoly of imported drugs in the future.
Antibody drug family mainly consists of monoclonal antibodies, which are specific drugs against tumors and characterized by strong targeting, high specificity, and low toxic and side effects. The global market concentration of antibody drugs is very high: Roche, AbbVie, J & J, and Amgen, the top 4 by market share, occupy a total of 60.5% market share, however, the marketing of two Chinese-produced anti-PD-1 drugs and many anti-PD-1/PD-L1 drugs to be marketed in the future give the Chinese people great confidence, and the low-cost high-quality antibody drugs bring hopes to more Chinese families.
In recent decade, recombinant cytokines produced using genetic engineering techniques in the world have good efficacy in treating tumors, hematopoietic disorders, and infections, etc. as biological response modifier. The marketing of the first-in-class new biological drug: Recombinant Cytokine Gene Derived Protein Injection ("Novaferon") in 2018 has brought more choices to the large population of hepatitis B patients in China.
Finally, let’s see the distribution of top 10 therapeutic areas.











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