Category:
Prophylactic Biological Products
CAS NO:
68291-97-4
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Basic Info
CAS Number
68291-97-4
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Zonisamide is a sulfonamide derivative anticonvulsant medication primarily utilized in the management of partial-onset seizures. Chemically, it possesses the molecular formula C8H10N2O3S and is identified by the CAS registry number 68291-97-4. Structurally, its unique composition distinguishes it from other antiepileptic drugs, featuring a sulfonamide group that contributes to its distinct pharmacological profile. This compound acts through multiple mechanisms to stabilize neuronal membranes and reduce seizure activity. Specifically, it blocks voltage-gated sodium channels, thereby inhibiting high-frequency repetitive firing of action potentials. Additionally, Zonisamide suppresses T-type calcium currents in thalamic neurons, which plays a crucial role in preventing the propagation of epileptic discharges. It also enhances GABAergic transmission, further promoting neuronal inhibition.
Clinically, Zonisamide is indicated as adjunctive therapy for adult patients with partial-onset seizures, though it is increasingly used off-label or approved in specific regions for broader epilepsy types. Its efficacy has been demonstrated in reducing seizure frequency across various clinical trials. Beyond epilepsy, emerging research suggests potential applications in migraine prophylaxis, neuropathic pain management, and even weight loss due to its appetite-suppressing side effects, although these uses remain under investigation. The drug is typically administered orally in capsule or tablet form, with dosing adjusted based on individual patient response and tolerability. Common adverse effects include somnolence, dizziness, anorexia, and cognitive dysfunction. Notably, as a sulfonamide, there is a risk of severe cutaneous reactions such as Stevens-Johnson syndrome, necessitating careful monitoring during initiation. Despite these risks, Zonisamide remains a valuable therapeutic option for patients who have not responded adequately to other antiepileptic agents, offering a versatile mechanism of action within modern neurology.
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