Category:
Prophylactic Biological Products
CAS NO:
330808-88-3
Standard:
USP,EP,
Vardenafil hydrochloride
| Status | Commercial |
| Therapeutic cat. | Erectile |
| Polymorphic form | Trihydrate form |
| CAS No. | 330808-88-3 |
| EU DMF readiness | |
| CEP | |
| CHINESE DMF | |
| JAPANESE DMF | |
| KOREAN DMF | |
| CANADIAN DMF | |
| US DMF readiness |
Drug description
Vardenafil is an oral therapy for erectile dysfunction that selectively inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, which activates guanylate cyclase and increases cGMP synthesis in the smooth muscle cells. PDE5 inhibitors like vardenafil prevent the degradation of cGMP, enhancing blood flow into the penis and resulting in an erection. Vardenafil is more potent than sildenafil and tadalafil in inhibiting PDE5, but it has lower selectivity for other PDE isoforms compared to tadalafil.