Category:
Prophylactic Biological Products
CAS NO:
57773-63-4
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Triptorelin Pamoate
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North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
57773-63-4
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Triptorelin Pamoate is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH), widely recognized for its pivotal role in the management of hormone-dependent conditions. Chemically, it consists of D-Tryptophan substituted at the sixth position with a pamoate salt, which significantly extends its half-life compared to native GnRH or other analogues like Triptorelin acetate. The molecular formula for Triptorelin Pamoate is C69H87N15O13P2, and it is identified by the CAS number 90493-42-2. This compound acts as a potent agonist that initially stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) upon administration. However, with continuous exposure, it causes downregulation and desensitization of GnRH receptors in the pituitary gland, leading to a profound suppression of sex steroid production.
The primary clinical applications of Triptorelin Pamoate include the treatment of advanced prostate cancer in men, where it effectively reduces testosterone levels to castrate concentrations, thereby slowing tumor progression. It is also utilized in women for managing endometriosis, uterine fibroids, and central precocious puberty. By inducing a hypoestrogenic state, it alleviates symptoms associated with these gynecological disorders. Furthermore, it plays a crucial role in assisted reproductive technologies, such as controlled ovarian stimulation protocols, preventing premature ovulation during in vitro fertilization cycles. The pamoate formulation allows for long-acting depot injections, typically administered every one, three, or six months, ensuring consistent therapeutic levels and improving patient compliance. While generally well-tolerated, side effects may include hot flashes, mood changes, and bone density loss due to hormonal suppression. As a cornerstone in endocrine therapy, Triptorelin Pamoate remains an essential pharmaceutical agent for regulating complex hormonal pathways in various medical specialties.
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