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CAS NO:
74285-86-2
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Basic Info
CAS Number
74285-86-2
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Triptophenolide, often associated with the bioactive compounds derived from *Tripterygium wilfordii* (Thunder God Vine), is a significant diterpenoid lactone studied extensively in natural product chemistry. While specific commercial availability of "Triptophenolide" as a standalone bulk chemical can be niche compared to its more famous counterparts like Triptolide or Celastrol, it represents a crucial structural class within this pharmacologically rich genus. The molecular framework typically consists of a complex tetracyclic skeleton featuring an epoxide bridge and multiple oxygenated functional groups, which are essential for its biological activity. Although exact CAS registry numbers vary depending on specific isomers or hydrate forms found in literature, compounds in this series generally share high molecular weights around 400-500 g/mol, reflecting their intricate terpene origin.
The primary application of Triptophenolide lies in biomedical research, particularly in the fields of oncology and immunology. Like other members of the tripterygium family, it exhibits potent anti-inflammatory properties by inhibiting key signaling pathways such as NF-κB and STAT3. This mechanism makes it a subject of intense investigation for treating autoimmune disorders, including rheumatoid arthritis and lupus, where uncontrolled immune responses cause severe tissue damage. Furthermore, emerging studies suggest that Triptophenolide possesses significant cytotoxic effects against various cancer cell lines, inducing apoptosis and arresting cell cycle progression without immediately affecting normal cells at lower concentrations. Its ability to suppress tumor angiogenesis further enhances its potential as an anticancer agent.
In the pharmaceutical industry, Triptophenolide serves as a valuable lead compound for drug development. Researchers utilize it to synthesize analogs with improved solubility and reduced toxicity profiles compared to traditional extracts. Beyond medicine, its structural complexity offers insights into evolutionary biosynthetic pathways in plants. However, due to the narrow therapeutic index common to this class of compounds, rigorous clinical trials are necessary before widespread therapeutic adoption. Currently, it remains primarily a tool for academic laboratories exploring novel mechanisms of action in inflammation and cancer biology. As global interest in natural product-derived therapeutics grows, Triptophenolide stands out as a promising candidate for future targeted therapies, bridging the gap between traditional herbal medicine and modern precision pharmacology.
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