Product Description
trimethoprim GMP veterinary in Chian 738-70-5
AI Product Description
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Trimethoprim, a synthetic bacteriostatic agent widely utilized in veterinary medicine under Good Manufacturing Practice (GMP) standards in China, serves as a critical component in antimicrobial therapy for livestock and companion animals. Its chemical identity is defined by the molecular formula C14H18N4O3 and the CAS registry number 738-70-5. Structurally, it functions as a dihydrofolate reductase inhibitor, disrupting bacterial folate synthesis essential for DNA replication and cell division. In clinical practice, Trimethoprim is rarely administered alone; it is most frequently combined with sulfadiazine or sulfa drugs to create a synergistic effect known as potentiated sulfonamide therapy. This combination significantly broadens the spectrum of activity against Gram-positive and Gram-negative bacteria, including pathogens like Escherichia coli, Staphylococcus aureus, and Salmonella species.
In the Chinese veterinary sector, GMP-compliant production ensures high purity, consistent potency, and rigorous quality control, meeting both national regulations and international safety benchmarks. The product is formulated into various dosage forms, including injectable solutions, oral tablets, granules for feed premixes, and topical preparations. It is primarily indicated for treating respiratory tract infections, urinary tract disorders, gastrointestinal infections, and skin conditions caused by susceptible organisms in cattle, swine, poultry, dogs, and cats. Due to concerns regarding antibiotic resistance and withdrawal periods, its usage strictly adheres to veterinary prescription guidelines and regulatory limits on residue levels in food-producing animals. Proper administration requires careful calculation based on animal weight and specific infection severity to prevent therapeutic failure or adverse reactions. As a cornerstone of modern veterinary pharmacology, Trimethoprim remains indispensable for maintaining herd health and ensuring food safety through effective disease management and controlled antibiotic stewardship.